Explain the importance of systematic review and meta-analysis for evidence-based

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Explain the importance of systematic review and meta-analysis for evidence-based

Explain the importance of systematic review and meta-analysis for evidence-based practice. What are the limitations of the systematic review? How to overcome the challenges? Offer an example of a situation when a systematic review and meta-analysis were one of the defining points in the decision-making process, and when without it the decision might have been incorrect. 
1 reference from class content 1 reference from outside 
https://training.cochrane.org/handbook
https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/1471-2288-11-15

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